IDEA AG - Publikationen

<h1>Publications</h1> <p><font color="#aa0000"><b>2008</b></font></p> <ul> <li>G. Cevc<br> Transfersomes: Innovative transdermal drug carriers. In: ‘Modified Release Drug Delivery Technology’, 2nd revised edition (M. Rathbone, M. Robert, J. Hadgraft, eds.) M. Dekker, New York, 2008, pp 319-332.</li> <li>G. Cevc, U. Vierl, S. Mazgareanu, M. Rother<br> Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels. Int. J. Pharm. in the press.</li> <li>G. Cevc, U. Vierl, S. Mazgareanu, M. Rother<br> Targeted delivery of an nonsteroidal anti-inflammatory agent into deep peripheral tissues. 1. Functional characterisation of a novel therapeutic product formulation based on self-regulating drug carriers. Int. J. Pharm., submitted for publication. </li> <li>G. Cevc, S. Mazgareanu, M. U. Vierl<br> Differential effect of occlusion on nonsteroidal anti-inflammatory agent delivery through the skin and into deep peripheral tissues from conventional topical products or the ultradeformable carrier formulation Int. J. Pharm., submitted for publication.</li> </ul> <p><font color="#aa0000"><b>2007</b></font></p> <ul> <li><a href="publications/pub2007_01.html" >G. Cevc, U. Vierl</a><br> Spatial distribution of cutaneous microvasculature and local drug clearance after drug application on the skin. J. Contr. Rel. 118, 18-26.</li> <li><a href="publications/pub2007_02.html" >M. Rother, B. J. Lavins, W. Kneer, K. Lehnhardt, E. J. Seidel, S. Mazgareanu.</a><br> Efficacy and safety of epicutaneous ketoprofen in Transfersome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomised controlled trial. Ann. Rheum. Dis. 66, 1178-1183.</li> <li>W. Kneer, K. Lehnhardt, E. J. Seidel, M. Rother, S. Mazgareanu<br> Innovative lokale Schmerztherapie mit Diractin® (Ketoprofen in Transfersom®) zur Behandlung der Kniegelenkarthrose. Orthop. Praxis. 43, 649-654.</li> </ul> <p><font color="#aa0000"><b>2005</b></font></p> <ul> <li><a href="publications/pub2005_01.html" >S. I. Simões, J. M. Tapadas, C.M. Marques, M. E. M. Cruz, M. B. F. Martins, G, Cevc. (2005)</a> <br> Permeabilisation and solubilisation of soybean phosphatidylcholine <br> bilayer vesicles, as membrane models, by polysorbate, Tween 80. Eur. <br> J. Pharm. Sci. 26, 307-317. </li> <li><a href="publications/pub2005_02.html" >S. I. Simões, T. C. Delgado, R. M. Lopes, S. Jesus, A. A. Ferreira, J. A. Morais, M. E. Cruz, M. L. Corvo, M. B. Martins</a><br> Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in Transfersomes. J. Contr. Rel. 103, 419-434.</li> </ul> <p><b><font color="#aa0000">2004</font></b></p> <p> <ul> <li><a href="publications/pub2004_03.html" >S. I. Simões, C. M.Marques, M. E. M. Cruz, G. Cevc, M. B. F. Martins</a><br> Cholate effect on solubilisation and permeability of simple and protein loaded phosphatidylcholine / sodium cholate mixed aggregates designed to mediate macromolecules transdermal delivery. Eur. J. Pharm. Biopharm. 58, 509-519.</li> <li><a href="publications/pub2004_02.html" ><font size="3">G. Cevc (2004)</font></a><font size="3"> <br> Lipid vesicles and other colloids as drug carriers on the skin. Advanced Drug Delivery Reviews, 56, 675– 711</font>.</li> <li><a href="publications/pub2004_01.html" ><font size="3">G.Cevc, G.Blume (2004)</font></a><font size="3"> <br> Hydrocortisone and dexamethasone in ultra-deformable drug carriers, Transfersomes®, have an increased biological potency and reduced therapeutic dosages. Biochim. Biophys. Acta 1663, 61-73</font></li> </ul> <p></p> <p><font color="#aa0000"><b>2003</b></font><font size="3"></font><font color="#aa0000"></font></p> <p> <ul> <font size="3"> <li><a href="publications/pub2003_05.html" >G. Cevc, A.Schätzlein, H. Richardsen, U. Vierl</a><br> Overcoming semi-permeable barriers, such as the skin, with ultradeformable mixed lipid vesicles, Transfersomes®, liposomes or mixed lipid micelles. Langmuir, 19, 10753-10763.</li> </font> <li><font size="3"><a href="publications/pub2003_04.html" >H. Fesq, J. Lehmann, A. Kontny, I. Erdmann, K . Theiling, M. Rother, J. Ring, G. Cevc and D. Abeck</a><br> Improved risk-benefit ratio for topical triamcinolone acetonide in Transfersome in comparison with equipotent cream and oinment: a randomized controlled trial. Therapeutics; British Journal of Dermatology; 149; 611 - 619.</font></li> <li><font size="3"><a href="publications/pub2003_03.html" >G. Cevc, G. Blume</a><br> Biological Activity and Characteristics of Triamcinolone-Acetonide formulated with the self-regulating Drug Carriers, Transfersomes® . Biochim. Biophys. Acta 1614:156-164.</font></li> <li><a href="publications/pub2003_02.html" >G. Cevc, D. Gebauer</a><br> Hydration driven transport of deformable lipid vesicles through fine pores and the skin barrier. Biophys. J. 84: 1010-1024.</li> <li><font size="3"><a href="publications/pub2003_01.html" >G. Cevc</a><br> Transdermal drug delivery of insulin with ultradeformable carriers, Transfersomes®. Clinical Pharmacokinetics 42: 461-474<i>. </i></font></li> </ul> <p><font color="#aa0000"><b>2002</b></font></p> <ul> <li><a href="publications/pub2002_01.html">G. Cevc</a><br> Transfersomes® - Innovative Transdermal Drug Carriers. In: Modified Release Drug Delivery Technology. (M. Rathbone, M. Robert, J. Hadgraft, eds.) M. Dekker, New York, pp 533-546.</li> <li><a href="publications/pub2002_03.html" >G. Cevc, A. Schätzlein, H. Richardsen</a><br> Ultradeformable Lipid Vesicles Can Penetrate the Skin and other Semi-Permeable Barriers Intact. Evidence from Double Label CLSM Experiments and Direct Size Measurements. Biochim. Biophys. Acta 1564:21-30.</li> <li><a href="publications/pub2002_04.html"> J. Lehmann, K. Theiling, M. Klede, A. Ikoma, M. Schmelz, M. Rother, P. von Wussow</a> <br> Expression of surrogate markers after transdermal delivery of interferon-alpha in Transfersomes®. Int. J. Immunother.18:21-26.</li> </ul> <p><font color="#aa0000"><b>2001</b></font></p> <ul> <li><a href="publications/pub2001_01.html" >G. Cevc, G. Blume<br> </a>New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochim. Biophys. Acta 1514:191-205.</li> <li><a href="publications/pub2001_02.html">J. Lehmann, S. Nissen-Meyer, S. Paul, M. Klede, A. Ikoma, M. Schmelz, M. Rother, G. Cevc<br> </a>Dermal tolerance and safety of an IFN alpha Transfersome® formulation. In: Skin and Environment - Perception and Protection. Proceedings of 10th EADV Congress, Munich. (J. Ring, S. Weidinger, U. Darsow, eds.) Monduzzi Editore, Bologna, 2001, pp:1031-1035.</li> </ul> <p><font color="#aa0000"><b>1999</b></font></p> <ul> <li><a href="publications/pub1999_01.html" >G. Cevc<br> </a>Overcoming the Skin Barrier with Artificial Smart Carriers of Drugs. In: Intelligent Materials for Controlled Release Technologies. (S.M. Dinh and J. DeNuzzio, A. R. Comfort, eds.) ACS Books, Washington, DC, pp 70-86.</li> </ul> <p><font color="#aa0000"><b>1998</b></font></p> <ul> <li><a href="publications/pub1998_01.html" >A. Paul, G. Cevc, B. K. Bachhawat<br> </a>Transdermal Immunization With Large Membrane Bound Molecules, Gap Junction Proteins, by Means of Ultradeformable Drug Carriers. Vaccine, 16, 188-195.</li> <li><a href="publications/pub1998_02.html" >G. Cevc, D. Gebauer, A. Schätzlein, G. Blume<br> </a>Ultraflexible Vesicles, Transfersomes, Transfersomes, Have an Extremely Low Permeation Resistance and Transport Therapeutic Amounts of Insulin Across the Intact Mammalian Skin. Biochim. Biophys. Acta 1368, 201-215.</li> <li><a href="publications/pub1998_03.html" >A. Schätzlein, G. Cevc<br> </a>Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes). Br. J. Dermatol. 138, 583-592.</li> <li><a href="publications/pub1998_04.html" >S. I. Simoes, H. C. Richardsen, M. B. Martins, M. E. Cruz, G. Cevc</a> Superoxide dismutase delivery through the narrow pores in skin models by flexible lipid aggregates. In: Proceedings of Control Release Society Satellite Meeting in Lissabon, 1998.</li> </ul> <p><font color="#aa0000"><b>1997</b></font></p> <ul> <li><a href="publications/pub1997_01.html" >G. Cevc<br> </a>Drug Delivery Across the Skin. Exp. Opin. Invest. Drugs, 6, 1887-1937.</li> </ul> <p><font color="#aa0000"><b>1996</b></font></p> <ul> <li><a href="publications/pub1996_01.html" >G. Cevc, G. Blume, A. Schätzlein, D. Gebauer, A. Paul<br> </a>The skin: a pathway for the systemic treatment with patches and lipid-based agent carriers. Adv. Drug Del. Rev. 18, 349-378.</li> <li><a href="publications/pub1996_02.html" >G. Cevc<br> </a>Lipid Suspensions on the Skin. Permeation Enhancement, Vesicle Penetration and Transdermal Drug Delivery. Crit. Rev. Therap. Drug Carrier Systems. 13, 257-388.</li> <li><a href="publications/pub1996_03.html" >G. Cevc, G. Blume, A. Schätzlein<br> </a>Transfersomes Mediated Transepidermal Delivery Improves the Regio-Specificity and Biological Activity of Corticosteroids in vivo. J. Contr. Rel. 45, 21, 1-226.</li> </ul> <p><font color="#aa0000"><b>1995</b></font></p> <ul> <li><a href="publications/pub1995_01.html" >G. Cevc<br> </a>Material Transport Across Permeability Barriers by Means of Lipid Vesicles. In: Handbook of Biological Physics. (Series ed. A. V. Hoff, Volume eds. R. Lipowsky, E. Sackmann), Vol. I, North-Holland, Chapter 9, pp 465-490.</li> <li><a href="publications/pub1995_02.html" >A. Paul, G. Cevc<br> </a>Non-Invasive Administration of Protein Antigens. Epicutaneous Immunization with the Bovine Serum Albumin. Vaccine Res. 4, 145-164.</li> <li><a href="publications/pub1995_03.html" >G. Cevc, A. Schätzlein, G. Blume<br> </a>Transdermal drug carriers: basic properties, optimization and transfer-efficiency in the case of epicutaneously applied peptides. J. Contr. Rel. 36, 3-16.</li> <li><a href="publications/pub1995_04.html" >G. Gompper, D.M. Kroll<br> </a>Driven transport of fluid vesicles through narrow pores. Phys. Rev. E 52, 4198-4208. </li> <li><a href="publications/pub1995_05.html" >A. Paul, G. Cevc, B. K. Bachhawat<br> </a>Transdermal Immunization With Large Proteins by Means of Ultradeformable Drug Carriers. Eur. J. Immunol. 25, 35221-3524.</li> <li><a href="publications/pub1995_06.html" >A. Schätzlein, G. Cevc<br> </a>Skin penetration by phospholipid vesicles, transfersomes, as visualized by means of the confocal laser scanning microscopy. In: Phospholipids: Characterization, Metabolism and Novel Biological Applications (G. Cevc, F. Paltauf, eds.) AOCS Press, Champain, IL, pp 191-209.</li> </ul> <p><font color="#aa0000"><b>1993</b></font></p> <ul> <li><a href="publications/pub1993_01.html" >G. Cevc<br> </a>Dermal Insulin. In: Frontiers in Insulin Pharmacology (M. Berger, and F. A. Gries, eds.), G. Thieme Verlag, Stuttgart, pp 161-169.</li> <li><a href="publications/pub1993_02.html" >G. Cevc, A. Schätzlein, D. Gebauer, G. Blume<br> </a>Ultra-high efficiency of drug and peptide transfer through the intact skin by means of novel drug-carriers, Transfersomes. In: Prediction of Percutaneous Penetration. (Bain, K. R., Hadgkraft, J., W. J. James, K. A. Water, eds.), STS Publishing, Cardiff, Volume 3b, pp 226-234.</li> </ul> <p><font color="#aa0000"><b>1992</b></font></p> <ul> <li><a href="publications/pub1992_01.html" >G. Cevc, G. Blume<br> </a>Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim. Biophys. Acta 1104, 226-232.</li> <li><a href="publications/pub1992_02.html" >P. Gonzalez, M. E. Planas, L. Rodriguez, S. Sanchez, G. Cevc<br> </a>Noninvasive, percutaneous induction of topical analgesia by a new type of drug carriers and prolongation of the local pain-insensitivity by analgesic liposomes. Anesth. Analg. 95, 615-621.</li> <li><a href="publications/pub1992_03.html" >G. Cevc<br> </a>Rationale for the Production and Dermal Application of Lipid Vesicles. In: Liposome Dermatic. (O. Braun-Falco, H.C. Korting, H.I. Maibach, eds.) Springer, Berlin, pp 82-90. <p> </p> </li> </ul> <p><a href="../index.html"><----</a> | <a href=".././index.html" target="_top" onmouseover="putstattext('Was ist das Besondere an IDEA?'); return true;">Startseite</a> | <a href="../about-us/index.html" target="_top" onmouseover="putstattext('Über die Geschichte, die Leute, die Zusammenarbeiten und die Zukunftspläne von IDEA.'); return true;">Über uns</a> | <a href="../corporate_factsheet/index.html" target="_top" onmouseover="putstattext('Corporate Factsheet'); return true;">Corporate Factsheet</a> | <a href="../science/index.html" target="_top" onmouseover="putstattext('Wissenschaftliche Kooperationen, Veröffenlichungen usw.'); return true;">Wissenschaft</a> | Publikationen | <a href="../product_opportunities/index.html" target="_top" onmouseover="putstattext(''); return true;">Einsatzmöglichkeiten</a> | <a href="../financial/index.html" target="_top" onmouseover="putstattext('Investoren und grundlegende finanzielle Daten.'); return true;">Finanzierung</a> | <a href="../press_releases/index.html" target="_top" onmouseover="putstattext('Originaltexte...'); return true;">Pressemitteilungen</a> | <a href="../latest_newsletter/index.html" target="_top" onmouseover="putstattext('IDEAS letzter ausgegebene Newsletter'); return true;">Letzter Newsletter</a> | <a href="../press_clippings/index.html" target="_top" onmouseover="putstattext('IDEA in der Presse - die Originaltexte.'); return true;">Pressespiegel</a> | <a href="../conferences/index.html" target="_top" onmouseover="putstattext('Bei diesen Veranstaltungen treffen sie uns, und wir können uns persönlich unterhalten...'); return true;">Konferenzen</a> | <a href="../career/index.html" target="_top" onmouseover="putstattext('Wir suchen Talente mit Engagement und bieten im Gegenzug viel.'); return true;">Karriere</a> | <a href="../contact/index.html" target="_top" onmouseover="putstattext('Wir freuen uns, von Ihnen zu hören!'); return true;">Kontakt</a> | <a href="../faq/index.html" target="_top" onmouseover="putstattext('Der Unterschied zwischen Liposomen und Transversomen, Produktverträglichkeit und vieles mehr.'); return true;">Wissenschaftliche FAQ</a> | <a href="../glossary/index.html" target="_top" onmouseover="putstattext(''); return true;">Glossar</a> | <a href="../sitemap/index.html" target="_top" onmouseover="putstattext('Schaffen Sie sich einen Eindruck von IDEA.'); return true;">Seitenübersicht</a> | <a href="../search/index.html" target="_top" onmouseover="putstattext('Finden Sie Dokumente in dieser Seite über Schlagwörter---'); return true;">Suchen</a> |  </p>