Material Transport Across Permeability Barriers by Means
of Lipid Vesicles.
G. Cevc
Medizinische Biophysik, Urologische Klinik und Poliklinik,
Klinikum r.d.I. Technische Universität München, Ismaningerstr. 22, 8000
München 80, Germany
In: Handbook of Biological Physics. (Series ed. A. V.
Hoff, Volume eds. R. Lipowsky, E. Sackmann), Vol. I, North-Holland, 1995,
Chapter 9, pp 465-490.
Simple lipid vesicles, liposomes, are unsuitable for the
transport of large amounts of material across the permeability barriers.
The flow of lipid vesicles through such barriers can be dramatically increased,
however, if the lipid bilayer deformability is enhanced. This can be achieved,
for example, by using optimized complex membranes with at least one edge-active
component. The resulting ultraflexible mixed lipid vesicles, Transfersomes,
can be pushed easily even through the pores which are much smaller than
the average vesicle diameter. Transfersomes, moreover, can move spontaneously
against the naturally occurring water concentration gradients. This phenomenon
is useful for bringing biologically active molecules across the intact
skin and into the body interior for the purposes of local and systemic
therapy.
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