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<p align="left"><b>Transfersomes Mediated Transepidermal Delivery Improves the Regio-Specificity and Biological Activity of Corticosteroids in vivo </b> </p> <p align="left">Gregor Cevc*, G. Blume,+ and A. Schätzlein*+ </p> <p align="left">+IDEA, Innovative dermale Applikationen GmbH, Frankfurter Ring 193a, <br> D-80807 München, Deutschland, EU<br> *Medizinische Biophysik, Klinikum r.d.I., Technische Universität München, Ismaningerstr. 22, D-81675 München, Deutschland, EU </p> <p align="left"><b>Journal of Controlled Release 45: 211-226 (1996).</b></p> <p align="left">Innovative, carrier-based suspensions of several commonly used corticosteroids are introduced. These formulations contain the recently developed agent carriers, Transfersomes, which are sufficiently deformable to penetrate into or across the intact skin barrier. The resulting drug delivery can be varied systematically: depending on the precise application conditions and carrier design, between 100 % and < 5 % of applied drug is deposited in the outermost skin region. Low area dose favours the drug retention in the skin and keeps the relative area under the curve for the blood pool below a few per cent, at most, of that resulting from the corresponding drug injection; transfersomes hence improve the specificity of topical drug delivery and the overall drug safety. Increasing the total applied drug dose, as well as the dose per area, promotes the systemic drug availability. After an epicutaneous application of sufficient drug amount, therapeutically meaningful agent concentration is reached in the blood. This normally happens after the lag time of approximately 4 h to 6 h. When hydrocortisone, dexamethasone, or triamcinolone-acetonide are administered epicutaneously in transfersomes, for example, at the dose of 1.5 mg/kg, 1.5 mg/kg, and 1 mg/kg, the respective concentrations of these drugs in the blood at t=8 h are approximately 0.4 µg/mL, near 0.75 µg/mL and 0.007 µg/mL. These results are comparable to those of a subcutaneous injection of (3 ... 10 x) lower amounts of the same drug. Concentration of the epicutaneously administered corticosteroids in the blood is always lower than in the skin, however, where 28 µg/g, 156 µg/g, and 10 µg/g are found for the above mentioned drug doses at t=8 h, respectively. Transfersome-based corticosteroids are biologically active at doses several times lower than that currently used in the dermatic formulations for the treatment of skin diseases. The biological anti-edema activity of transfersomal corticosteroid formulations hence exceeds that of the corresponding commercial products, probably owing to the superior drug targeting potential in the organ.</p> <p><a href="index.html"><----</a> | <a href="../.././index.html" target="_top" onmouseover="putstattext('Was ist das Besondere an IDEA?'); return true;">Startseite</a> | <a href="../../about-us/index.html" target="_top" onmouseover="putstattext('Über die Geschichte, die Leute, die Zusammenarbeiten und die Zukunftspläne von IDEA.'); return true;">Über uns</a> | <a href="../../corporate_factsheet/index.html" target="_top" onmouseover="putstattext('Corporate Factsheet'); return true;">Corporate Factsheet</a> | Wissenschaft | <a href="../../publications/index.html" target="_top" onmouseover="putstattext('Publikationen'); return true;">Publikationen</a> | <a href="../../product_opportunities/index.html" target="_top" onmouseover="putstattext(''); return true;">Einsatzmöglichkeiten</a> | <a href="../../financial/index.html" target="_top" onmouseover="putstattext('Investoren und grundlegende finanzielle Daten.'); return true;">Finanzierung</a> | <a href="../../press_releases/index.html" target="_top" onmouseover="putstattext('Originaltexte...'); return true;">Pressemitteilungen</a> | <a href="../../latest_newsletter/index.html" target="_top" onmouseover="putstattext('IDEAS letzter ausgegebene Newsletter'); return true;">Letzter Newsletter</a> | <a href="../../press_clippings/index.html" target="_top" onmouseover="putstattext('IDEA in der Presse - die Originaltexte.'); return true;">Pressespiegel</a> | <a href="../../conferences/index.html" target="_top" onmouseover="putstattext('Bei diesen Veranstaltungen treffen sie uns, und wir können uns persönlich unterhalten...'); return true;">Konferenzen</a> | <a href="../../career/index.html" target="_top" onmouseover="putstattext('Wir suchen Talente mit Engagement und bieten im Gegenzug viel.'); return true;">Karriere</a> | <a href="../../contact/index.html" target="_top" onmouseover="putstattext('Wir freuen uns, von Ihnen zu hören!'); return true;">Kontakt</a> | <a href="../../faq/index.html" target="_top" onmouseover="putstattext('Der Unterschied zwischen Liposomen und Transversomen, Produktverträglichkeit und vieles mehr.'); return true;">Wissenschaftliche FAQ</a> | <a href="../../glossary/index.html" target="_top" onmouseover="putstattext(''); return true;">Glossar</a> | <a href="../../sitemap/index.html" target="_top" onmouseover="putstattext('Schaffen Sie sich einen Eindruck von IDEA.'); return true;">Seitenübersicht</a> | <a href="../../search/index.html" target="_top" onmouseover="putstattext('Finden Sie Dokumente in dieser Seite über Schlagwörter---'); return true;">Suchen</a> |  </p>