IDEA AG - Product Opportunities - Regio-Selective Therapeutics

<h3>Regio-selective therapeutics<br> - Delivery to deep skin and underlying muscles/joints</h3> <p>Drugs can be delivered with <a href="../faq/index-transfersome.html" >Transfersomes®</a> in a fashion that avoids, to a great extent, the clearance through the skin capillary bed (peripheral blood-capillary plexus). This permits the drugs to penetrate the skin and reach the underlying tissue in amounts substantially higher than those achieved with conventional topical formulations. Compared to oral preparations, the regional delivery by Transfersome® formulation can provide a faster onset and a longer duration of action. IDEA's drug delivery approach also substantially lowers systemic drug concentration, and thus diminishes the danger of systemic adverse effects. </p> <div align="center"><img src="../../img/product_opportunities/diclofen.gif" width="440" height="299" alt="image cannot be shown"></div> <p class="caption"><i> Diclofenac applied on the skin in Transfersomes® is delivered site-specifically into deep muscular tissue. In contrast, a much higher drug dose administered epicutaneously in a hydrogel is poorly targeted and does not reach therapeutic local drug concentrations, except through the blood.</i> </p> <p align="left">An example for the successful regional delivery of a small drug by Transfersomes® are formulations of nonsteroidal anti-inflammatory drugs (NSAIDs). A comparison with the performance of the traditional topical hydrogel formulation is made for the popular drug diclofenac in the illustration above. </p> <p align="left">A therapeutically meaningful diclofenac concentration in the target muscle tissue is reached even when the locally administered drug dose in Transfersomes® is much lower than the amount typically used with a commercial hydrogel.</p> <p align="left">In pigs, for example, it is sufficient to use merely 0.3 mg diclofenac in highly deformable Transfersomes® per kg body weight, spread over an area of 25 cm², to ensure therapeutic drug concentration in a 5 cm thick muscle specimen, collected under the agent application site. The concurrently measured systemic drug level is nearly an order of magnitude lower. In contrast, if the drug is used in a hydrogel at an 8 times higher dose, the average intramuscular concentration is three times below the therapeutic level. and comparable to that measured in the serum.</p> <p align="left">NSAID formulations with Transfersomes® were also shown already to be clinically effective. This is illustrated in the following figure for a different NSAID.<br>   <br> </p> <div align="center"> <img src="../../img/product_opportunities/vaspid.gif" width="440" height="299" map="#vaspid" alt="[VASPID chart]" border="0" usemap="#vaspid"> <map name="vaspid"> <area shape="rect" coords="21,15,44,225" href="../glossary/index-vaspid.html#vapid" target="_blank" alt="[Glossary: VASPID]"> </map> <p class="caption"><i>An NSAID applied on the skin in Transfersomes® ensures good local therapeutic effect, comparable to that of an equally dosed oral product. The result obtained with a conventional commercial topical product is much worse and does not differ from placebo.</i></p> </div> <p><a href="index.html"><----</a> | <a href=".././index.html" target="_top" onmouseover="putstattext('What is special about IDEA?'); return true;">Home</a> | <a href="../about-us/index.html" target="_top" onmouseover="putstattext('About IDEA history, people, external collaboratory and future plans.'); return true;">About us</a> | <a href="../corporate_factsheet/index.html" target="_top" onmouseover="putstattext('Corporate Factsheet'); return true;">Corporate Factsheet</a> | <a href="../science/index.html" target="_top" onmouseover="putstattext('Academic collaborations, publications, etc.'); return true;">Science</a> | <a href="../publications/index.html" target="_top" onmouseover="putstattext('Publications'); return true;">Publications</a> | Product opportunities | <a href="../financial/index.html" target="_top" onmouseover="putstattext('Investors and basic financial data.'); return true;">Finance</a> | <a href="../press_releases/index.html" target="_top" onmouseover="putstattext('Original texts.'); return true;">Press releases</a> | <a href="../latest_newsletter/index.html" target="_top" onmouseover="putstattext('IDEAS latest newsletter'); return true;">Latest newsletter</a> | <a href="../press_clippings/index.html" target="_top" onmouseover="putstattext('IDEA in the press.'); return true;">Press clippings</a> | <a href="../conferences/index.html" target="_top" onmouseover="putstattext('Here you will find many dates where you can meet us and where we can talk...'); return true;">Conferences</a> | <a href="../career/index.html" target="_top" onmouseover="putstattext('We constantly seek best talents and dedication, offering much in return.'); return true;">Career</a> | <a href="../contact/index.html" target="_top" onmouseover="putstattext('We would like to hear from you!'); return true;">Contact</a> | <a href="../faq/index.html" target="_top" onmouseover="putstattext('Product bio/acceptability, liposome/Transfersome, ...'); return true;">Scientific FAQ</a> | <a href="../glossary/index.html" target="_top" onmouseover="putstattext(''); return true;">Glossary</a> | <a href="../sitemap/index.html" target="_top" onmouseover="putstattext('Get an impression on IDEA!'); return true;">Site Map</a> | <a href="../search/index.html" target="_top" onmouseover="putstattext('Find documents based on keywords!'); return true;">Search</a> |  </p>