IDEA AG - Publications

<h1>Publications</h1> <p><font color="#aa0000"><b>2010</b></font></p> <ul> <li>G. Cevc, U. Vierl (2010) <br> Nanotechnology and the transdermal route. A state of the art review and critical appraisal. J. Contr. Rel. 141, 277-299. </li> </ul> <p><font color="#aa0000"><b>2009</b></font></p> <ul> <li><a href="publications/pub2008_05.html" >W. Kneer, I. Rother, M. Rother, E. Seidel for the IDEA-033-III-01 Study Group (2009) </a><br> A Multiple-Dose, Open-Label, Safety, Compliance, and Usage Evaluation Study of Epicutaneously Applied Diractin® (Ketoprofen in Transfersome®) in Joint/Musculoskeletal Pain or Soft Tissue Inflammation. Curr. Drug Saf. 4, 5-10.</li> <li>S. Simões, C. Marques, M. E. Cruz, M. B. Martins (2009) <br> Anti-inflammatory effects of locally applied enzyme-loaded ultradeformable vesicles on an acute cutaneous model. J. Microencapsul. 26, 649-658.</li> <li>M. Rother, E. J. Seidel, P. M. Clarkson, S., Mazgareanu, U. Vierl, I. Rother (2009) <br> Efficacy of epicutaneous Diractin® (ketoprofen in Transfersome® gel) for the treatment of pain related to eccentric muscle contractions. Drug Design, Development and Therapy 3, 143–149.</li> <li>M. M. Elsayed, U. Vierl, G. Cevc (2009) <br> Accurate potentiometric determination of lipid membrane-water partition coefficients and apparent dissociation constants of ionizable drugs: electrostatic corrections. Pharm. Res. 26, 1332-1343.</li> </ul> <p><font color="#aa0000"><b>2008</b></font></p> <ul> <li>G. Cevc<br> Transfersomes: Innovative transdermal drug carriers. In: ‘Modified Release Drug Delivery Technology’, 2nd revised edition (M. Rathbone, M. Robert, J. Hadgraft, eds.) M. Dekker, New York, 2008, pp 319-332.</li> <li><a href="publications/pub2008_01.html" >G. Cevc, S. Mazgareanu, M. Rother</a><br> Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels.Int. J. Pharm. 360, 29-39. </li> <li><a href="publications/pub2008_02.html" >G. Cevc, S. Mazgareanu, M. Rother, U. Vierl</a><br> Occlusion effect on transcutaneous NSAID delivery from conventional and carrier-based formulations Int. J. Pharm. 359, 190-197.</li> <li><a href="publications/pub2008_03.html" >G. Cevc, U. Vierl, S. Mazgareanu</a><br> Functional characterisation of novel analgesic product based on self-regulating drug carrierss. Int. J. Pharm. 360, 18-28.</li> <li><a href="publications/pub2008_04.html" >C. Wachter, U. Vierl, G. Cevc</a><br> Adaptability and elasticity of the mixed lipid bilayer vesicles containing non-ionic surfactant designed for targeted drug delivery across the skin. J. Drug Targeting 16, 611-625.</li> </ul> <p><font color="#aa0000"><b>2007</b></font></p> <ul> <li><a href="publications/pub2007_01.html" >G. Cevc, U. Vierl</a><br> Spatial distribution of cutaneous microvasculature and local drug clearance after drug application on the skin. J. Contr. Rel. 118, 18-26.</li> <li><a href="publications/pub2007_02.html" >M. Rother, B. J. Lavins, W. Kneer, K. Lehnhardt, E. J. Seidel, S. Mazgareanu.</a><br> Efficacy and safety of epicutaneous ketoprofen in Transfersome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomised controlled trial. Ann. Rheum. Dis. 66, 1178-1183.</li> <li><a href="publications/pub2007_03.html" >W. Kneer, K. Lehnhardt, E. J. Seidel, M. Rother, S. Mazgareanu</a><br> Innovative lokale Schmerztherapie mit Diractin® (Ketoprofen in Transfersom®) zur Behandlung der Kniegelenkarthrose. Orthop. Praxis. 43, 649-654.</li> </ul> <p><font color="#aa0000"><b>2005</b></font></p> <ul> <li><a href="publications/pub2005_01.html" >S. I. Simões, J. M. Tapadas, C.M. Marques, M. E. M. Cruz, M. B. F. Martins, G, Cevc. (2005)</a> <br> Permeabilisation and solubilisation of soybean phosphatidylcholine <br> bilayer vesicles, as membrane models, by polysorbate, Tween 80. Eur. <br> J. Pharm. Sci. 26, 307-317. </li> <li><a href="publications/pub2005_02.html" >S. I. Simões, T. C. Delgado, R. M. Lopes, S. Jesus, A. A. Ferreira, J. A. Morais, M. E. Cruz, M. L. Corvo, M. B. Martins</a><br> Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in Transfersomes. J. Contr. Rel. 103, 419-434.</li> </ul> <p><b><font color="#aa0000">2004</font></b></p> <ul> <li><a href="publications/pub2004_03.html" >S. I. Simões, C. M.Marques, M. E. M. Cruz, G. Cevc, M. B. F. Martins</a><br> Cholate effect on solubilisation and permeability of simple and protein loaded phosphatidylcholine / sodium cholate mixed aggregates designed to mediate macromolecules transdermal delivery. Eur. J. Pharm. Biopharm. 58, 509-519.</li> <li><a href="publications/pub2004_02.html" ><font size="3">G. Cevc (2004)</font></a><font size="3"> <br> Lipid vesicles and other colloids as drug carriers on the skin. Advanced Drug Delivery Reviews, 56, 675– 711</font>.</li> <li><a href="publications/pub2004_01.html" ><font size="3">G.Cevc, G.Blume (2004)</font></a><font size="3"> <br> Hydrocortisone and dexamethasone in ultra-deformable drug carriers, Transfersomes®, have an increased biological potency and reduced therapeutic dosages. Biochim. Biophys. Acta 1663, 61-73</font></li> </ul> <p><font color="#aa0000"><b>2003</b></font><font size="3"></font></p> <ul> <font size="3"> <li><a href="publications/pub2003_05.html" >G. Cevc, A.Schätzlein, H. Richardsen, U. Vierl</a><br> Overcoming semi-permeable barriers, such as the skin, with ultradeformable mixed lipid vesicles, Transfersomes®, liposomes or mixed lipid micelles. Langmuir, 19, 10753-10763.</li> </font> <li><font size="3"><a href="publications/pub2003_04.html" >H. Fesq, J. Lehmann, A. Kontny, I. Erdmann, K . Theiling, M. Rother, J. Ring, G. Cevc and D. Abeck</a><br> Improved risk-benefit ratio for topical triamcinolone acetonide in Transfersome in comparison with equipotent cream and oinment: a randomized controlled trial. Therapeutics; British Journal of Dermatology; 149; 611 - 619.</font></li> <li><font size="3"><a href="publications/pub2003_03.html" >G. Cevc, G. Blume</a><br> Biological Activity and Characteristics of Triamcinolone-Acetonide formulated with the self-regulating Drug Carriers, Transfersomes® . Biochim. Biophys. Acta 1614:156-164.</font></li> <li><a href="publications/pub2003_02.html" >G. Cevc, D. Gebauer</a><br> Hydration driven transport of deformable lipid vesicles through fine pores and the skin barrier. Biophys. J. 84: 1010-1024.</li> <li><font size="3"><a href="publications/pub2003_01.html" >G. Cevc</a><br> Transdermal drug delivery of insulin with ultradeformable carriers, Transfersomes®. Clinical Pharmacokinetics 42: 461-474<i>. </i></font></li> </ul> <p><font color="#aa0000"><b>2002</b></font></p> <ul> <li><a href="publications/pub2002_01.html">G. Cevc</a><br> Transfersomes® - Innovative Transdermal Drug Carriers. In: Modified Release Drug Delivery Technology. (M. Rathbone, M. Robert, J. Hadgraft, eds.) M. Dekker, New York, pp 533-546.</li> <li><a href="publications/pub2002_03.html" >G. Cevc, A. Schätzlein, H. Richardsen</a><br> Ultradeformable Lipid Vesicles Can Penetrate the Skin and other Semi-Permeable Barriers Intact. Evidence from Double Label CLSM Experiments and Direct Size Measurements. Biochim. Biophys. Acta 1564:21-30.</li> </ul> <p><font color="#aa0000"><b>2001</b></font></p> <ul> <li><a href="publications/pub2001_01.html" >G. Cevc, G. Blume<br> </a>New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochim. Biophys. Acta 1514:191-205.</li> <li><a href="publications/pub2001_02.html">J. Lehmann, S. Nissen-Meyer, S. Paul, M. Klede, A. Ikoma, M. Schmelz, M. Rother, G. Cevc<br> </a>Dermal tolerance and safety of an IFN alpha Transfersome® formulation. In: Skin and Environment - Perception and Protection. Proceedings of 10th EADV Congress, Munich. (J. Ring, S. Weidinger, U. Darsow, eds.) Monduzzi Editore, Bologna, 2001, pp:1031-1035.</li> </ul> <p><font color="#aa0000"><b>1999</b></font></p> <ul> <li><a href="publications/pub1999_01.html" >G. Cevc<br> </a>Overcoming the Skin Barrier with Artificial Smart Carriers of Drugs. In: Intelligent Materials for Controlled Release Technologies. (S.M. Dinh and J. DeNuzzio, A. R. Comfort, eds.) ACS Books, Washington, DC, pp 70-86.</li> <li>H. Fesq, P. Hutzler, H. Richardsen, G. Cevc, J. Ring, D. Abeck<br> Detection of transepidermal intercluster gaps in human epidermis with the help of highly deformable lipid vesicles (Transfersomes) and confocal laser scanning microscopy. Arch. Dermatol. Res. 291, 130.</li> <li>G. Cevc, H. Richardsen<br> Lipid vesicles and membrane fusion. Adv. Drug. Delivery Rev. 38, 207-232.</li> </ul> <p><font color="#aa0000"><b>1998</b></font></p> <ul> <li><a href="publications/pub1998_01.html" >A. Paul, G. Cevc, B. K. Bachhawat<br> </a>Transdermal Immunization With Large Membrane Bound Molecules, Gap Junction Proteins, by Means of Ultradeformable Drug Carriers. Vaccine, 16, 188-195.</li> <li><a href="publications/pub1998_02.html" >G. Cevc, D. Gebauer, A. Schätzlein, G. Blume<br> </a>Ultraflexible Vesicles, Transfersomes, Transfersomes, Have an Extremely Low Permeation Resistance and Transport Therapeutic Amounts of Insulin Across the Intact Mammalian Skin. Biochim. Biophys. Acta 1368, 201-215.</li> <li><a href="publications/pub1998_03.html" >A. Schätzlein, G. Cevc<br> </a>Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes). Br. J. Dermatol. 138, 583-592.</li> </ul> <p><font color="#aa0000"><b>1997</b></font></p> <ul> <li><a href="publications/pub1997_01.html" >G. Cevc<br> </a>Drug Delivery Across the Skin. Exp. Opin. Invest. Drugs, 6, 1887-1937.</li> <li><a href="publications/pub1996_03.html" >G. Cevc, G. Blume, A. Schätzlein<br> </a>Transfersomes Mediated Transepidermal Delivery Improves the Regio-Specificity and Biological Activity of Corticosteroids in vivo. J. Contr. Rel. 45, 21, 1-226.</li> </ul> <p><font color="#aa0000"><b>1996</b></font></p> <ul> <li><a href="publications/pub1996_01.html" >G. Cevc, G. Blume, A. Schätzlein, D. Gebauer, A. Paul<br> </a>The skin: a pathway for the systemic treatment with patches and lipid-based agent carriers. Adv. Drug Del. Rev. 18, 349-378.</li> <li><a href="publications/pub1996_02.html" >G. Cevc<br> </a>Lipid Suspensions on the Skin. Permeation Enhancement, Vesicle Penetration and Transdermal Drug Delivery. Crit. Rev. Therap. Drug Carrier Systems. 13, 257-388.</li> </ul> <p><font color="#aa0000"><b>1995</b></font></p> <ul> <li><a href="publications/pub1995_01.html" >G. Cevc<br> </a>Material Transport Across Permeability Barriers by Means of Lipid Vesicles. In: Handbook of Biological Physics. (Series ed. A. V. Hoff, Volume eds. R. Lipowsky, E. Sackmann), Vol. I, North-Holland, Chapter 9, pp 465-490.</li> <li><a href="publications/pub1995_02.html" >A. Paul, G. Cevc<br> </a>Non-Invasive Administration of Protein Antigens. Epicutaneous Immunization with the Bovine Serum Albumin. Vaccine Res. 4, 145-164.</li> <li><a href="publications/pub1995_03.html" >G. Cevc, A. Schätzlein, G. Blume<br> </a>Transdermal drug carriers: basic properties, optimization and transfer-efficiency in the case of epicutaneously applied peptides. J. Contr. Rel. 36, 3-16.</li> <li><a href="publications/pub1995_04.html" >G. Gompper, D.M. Kroll<br> </a>Driven transport of fluid vesicles through narrow pores. Phys. Rev. E 52, 4198-4208. </li> <li><a href="publications/pub1995_05.html" >A. Paul, G. Cevc, B. K. Bachhawat<br> </a>Transdermal Immunization With Large Proteins by Means of Ultradeformable Drug Carriers. Eur. J. Immunol. 25, 35221-3524.</li> <li><a href="publications/pub1995_06.html" >A. Schätzlein, G. Cevc<br> </a>Skin penetration by phospholipid vesicles, transfersomes, as visualized by means of the confocal laser scanning microscopy. In: Phospholipids: Characterization, Metabolism and Novel Biological Applications (G. Cevc, F. Paltauf, eds.) AOCS Press, Champain, IL, pp 191-209.</li> </ul> <p><font color="#aa0000"><b>1993</b></font></p> <ul> <li><a href="publications/pub1993_01.html" >G. Cevc<br> </a>Dermal Insulin. In: Frontiers in Insulin Pharmacology (M. Berger, and F. A. Gries, eds.), G. Thieme Verlag, Stuttgart, pp 161-169.</li> <li><a href="publications/pub1993_02.html" >G. Cevc, A. Schätzlein, D. Gebauer, G. Blume<br> </a>Ultra-high efficiency of drug and peptide transfer through the intact skin by means of novel drug-carriers, Transfersomes. In: Prediction of Percutaneous Penetration. (Bain, K. R., Hadgkraft, J., W. J. James, K. A. Water, eds.), STS Publishing, Cardiff, Volume 3b, pp 226-234.</li> </ul> <p><font color="#aa0000"><b>1992</b></font></p> <ul> <li><a href="publications/pub1992_01.html" >G. Cevc, G. Blume<br> </a>Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim. Biophys. Acta 1104, 226-232.</li> <li><a href="publications/pub1992_02.html" >P. Gonzalez, M. E. Planas, L. Rodriguez, S. Sanchez, G. Cevc<br> </a>Noninvasive, percutaneous induction of topical analgesia by a new type of drug carriers and prolongation of the local pain-insensitivity by analgesic liposomes. Anesth. Analg. 95, 615-621.</li> <li><a href="publications/pub1992_03.html" >G. Cevc<br> </a>Rationale for the Production and Dermal Application of Lipid Vesicles. In: Liposome Dermatic. (O. Braun-Falco, H.C. Korting, H.I. Maibach, eds.) Springer, Berlin, pp 82-90. <p> </p> </li> </ul> <p><a href="../index.html"><----</a> | <a href=".././index.html" target="_top" onmouseover="putstattext('What is special about IDEA?'); return true;">Home</a> | <a href="../about-us/index.html" target="_top" onmouseover="putstattext('About IDEA history, people, external collaboratory and future plans.'); return true;">About us</a> | <a href="../corporate_factsheet/index.html" target="_top" onmouseover="putstattext('Corporate Factsheet'); return true;">Corporate Factsheet</a> | <a href="../science/index.html" target="_top" onmouseover="putstattext('Academic collaborations, publications, etc.'); return true;">Science</a> | Publications | <a href="../product_opportunities/index.html" target="_top" onmouseover="putstattext('IDEA offers better compliance, local drug targeting and patent protection.'); return true;">Product opportunities</a> | <a href="../financial/index.html" target="_top" onmouseover="putstattext('Investors and basic financial data.'); return true;">Finance</a> | <a href="../press_releases/index.html" target="_top" onmouseover="putstattext('Original texts.'); return true;">Press releases</a> | <a href="../latest_newsletter/index.html" target="_top" onmouseover="putstattext('IDEAS latest newsletter'); return true;">Latest newsletter</a> | <a href="../press_clippings/index.html" target="_top" onmouseover="putstattext('IDEA in the press.'); return true;">Press clippings</a> | <a href="../conferences/index.html" target="_top" onmouseover="putstattext('Here you will find many dates where you can meet us and where we can talk...'); return true;">Conferences</a> | <a href="../career/index.html" target="_top" onmouseover="putstattext('We constantly seek best talents and dedication, offering much in return.'); return true;">Career</a> | <a href="../contact/index.html" target="_top" onmouseover="putstattext('We would like to hear from you!'); return true;">Contact</a> | <a href="../faq/index.html" target="_top" onmouseover="putstattext('Product bio/acceptability, liposome/Transfersome, ...'); return true;">Scientific FAQ</a> | <a href="../glossary/index.html" target="_top" onmouseover="putstattext(''); return true;">Glossary</a> | <a href="../sitemap/index.html" target="_top" onmouseover="putstattext('Get an impression on IDEA!'); return true;">Site Map</a> | <a href="../search/index.html" target="_top" onmouseover="putstattext('Find documents based on keywords!'); return true;">Search</a> |  </p>